Article
Structural characterization of the catalytic site of a Nilaparvata lugens delta-class glutathione transferase.
Archives of biochemistry and biophysics - 15 Jan 2015
Yamamoto Kohji, Higashiura Akifumi, Hossain Md Tofazzal, Yamada Naotaka, Shiotsuki Takahiro, Nakagawa Atsushi
Abstract excerpt
Glutathione transferases (GSTs) are a major class of detoxification enzymes that play a central role in the defense against environmental toxicants and oxidative stress. Here, we studied the crystal structure of a delta-class glutathione transferase from Nilaparvata lugens, nlGSTD, to gain insights into its catalytic mechanism. The structure of nlGSTD in complex with glutathione, determined at a resolution of...
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