Article
Structural insight into the active site of a Bombyx mori unclassified glutathione transferase.
Bioscience, biotechnology, and biochemistry - 1 Jan 2015
Hossain Md Tofazzal, Yamamoto Kohji
Abstract excerpt
Glutathione transferases (GSTs) are major detoxification enzymes that play central roles in the defense against various environmental toxicants as well as oxidative stress. Here, we identify amino acid residues of an unclassified GST from Bombyx mori, bmGSTu-interacting glutathione (GSH). Site-directed mutagenesis of bmGSTu mutants indicated that amino acid residues Asp103, Ser162, and Ser166 contribute to...
Topics
- Animals
- Bombyx
- Catalytic Domain
- Glutathione
- Glutathione Transferase
- Models, Molecular
- Mutagenesis, Site-Directed
- Mutation