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Article

Function of conserved residues of human glutathione synthetase: implications for the ATP-grasp enzymes.

The Journal of biological chemistry - 21 May 2004

Dinescu Adriana, Cundari Thomas R, Bhansali Vikas S, Luo Jia-Li, Anderson Mary E

Abstract excerpt

Glutathione synthetase is an enzyme that belongs to the glutathione synthetase ATP-binding domain-like superfamily. It catalyzes the second step in the biosynthesis of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione synthetase has been purified and sequenced from a variety of biological sources; still, its exact mechanism is not fully understood. A variety of structural...

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PMID: 14990577
DOI: 10.1074/jbc.M401334200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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