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Article

Added value of whole-genome sequencing for management of highly drug-resistant TB

9 Dec 2014

Abstract excerpt

OBJECTIVES: Phenotypic drug susceptibility testing (DST) for Mycobacterium tuberculosis takes several weeks to complete and second-line DST is often poorly reproducible, potentially leading to compromised clinical decisions. Following a fatal case of XDR TB, we investigated the potential benefit of using whole-genome sequencing to generate an in silico drug susceptibility profile. METHODS: The clinical course of...

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PMID: 25492392
DOI: 10.1093/jac/dku508

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