Article
Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing.
The New England journal of medicine - 11 Oct 2018
Allix-Béguec Caroline, Arandjelovic Irena, Bi Lijun, Beckert Patrick, Bonnet Maryline, Bradley Phelim, Cabibbe Andrea M, Cancino-Muñoz Irving, Caulfield Mark J, Chaiprasert Angkana, Cirillo Daniela M, Clifton David A, Comas Iñaki, Crook Derrick W, De Filippo Maria R, de Neeling Han, Diel Roland, Drobniewski Francis A, Faksri Kiatichai, Farhat Maha R, Fleming Joy, Fowler Philip, Fowler Tom A, Gao Qian, Gardy Jennifer, Gascoyne-Binzi Deborah, Gibertoni-Cruz Ana-Luiza, Gil-Brusola Ana, Golubchik Tanya, Gonzalo Ximena, Grandjean Louis, He Guangxue, Guthrie Jennifer L, Hoosdally Sarah, Hunt Martin, Iqbal Zamin, Ismail Nazir, Johnston James, Khanzada Faisal M, Khor Chiea C, Kohl Thomas A, Kong Clare, Lipworth Sam, Liu Qingyun, Maphalala Gugu, Martinez Elena, Mathys Vanessa, Merker Matthias, Miotto Paolo, Mistry Nerges, Moore David A J, Murray Megan, Niemann Stefan, Omar Shaheed V, Ong Rick T-H, Peto Tim E A, Posey James E, Prammananan Therdsak, Pym Alexander, Rodrigues Camilla, Rodrigues Mabel, Rodwell Timothy, Rossolini Gian M, Sánchez Padilla Elisabeth, Schito Marco, Shen Xin, Shendure Jay, Sintchenko Vitali, Sloutsky Alex, Smith E Grace, Snyder Matthew, Soetaert Karine, Starks Angela M, Supply Philip, Suriyapol Prapat, Tahseen Sabira, Tang Patrick, Teo Yik-Ying, Thuong Thuong N T, Thwaites Guy, Tortoli Enrico, van Soolingen Dick, Walker A Sarah, Walker Timothy M, Wilcox Mark, Wilson Daniel J, Wyllie David, Yang Yang, Zhang Hongtai, Zhao Yanlin, Zhu Baoli
Abstract excerpt
BACKGROUND: The World Health Organization recommends drug-susceptibility testing of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment decisions and improve outcomes. Whether DNA sequencing can be used to accurately predict profiles of susceptibility to first-line antituberculosis drugs has not been clear. METHODS: We obtained whole-genome sequences and associated phenotypes...
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