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Article

p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression.

PloS one - 1 Jan 2014

Novello Chiara, Pazzaglia Laura, Conti Amalia, Quattrini Irene, Pollino Serena, Perego Paola, Picci Piero, Benassi Maria Serena

Abstract excerpt

Osteosarcoma (OS) is the most common primary malignant bone tumor and prevalently occurs in the second decade of life. Etoposide, a chemotherapeutic agent used in combined treatments of recurrent human OS, belongs to the topoisomerase inhibitor family and causes DNA breakage. In this study we evaluated the cascade of events determined by etoposide-induced DNA damage in OS cell lines with different p53 status...

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Source

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Identifiers

PMID: 25490093
DOI: 10.1371/journal.pone.0114757
PMCID: PMC4260944

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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