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Article

Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.

PloS one - 1 Jan 2014

Fan Yuen Ngan, Meley Daniel, Pizer Barry, Sée Violaine

Abstract excerpt

Chemotherapeutic drug resistance and relapse remains a major challenge for paediatric (medulloblastoma) and adult (glioblastoma) brain tumour treatment. Medulloblastoma tumours and cell lines with mutations in the p53 signalling pathway have been shown to be specifically insensitive to DNA damaging agents. The aim of this study was to investigate the potential of triggering cell death in p53 mutated...

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Share to Brain Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, p53

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Source

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Identifiers

PMID: 25250818
DOI: 10.1371/journal.pone.0108514
PMCID: PMC4177398

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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