Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer.

doi:10.1002/emmm.201201504

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Article

Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer.

EMBO molecular medicine - 1 May 2013

Sonego Maura, Schiappacassi Monica, Lovisa Sara, Dall'Acqua Alessandra, Bagnoli Marina, Lovat Francesca, Libra Massimo, D'Andrea Sara, Canzonieri Vincenzo, Militello Loredana, Napoli Marco, Giorda Giorgio, Pivetta Barbara, Mezzanzanica Delia, Barbareschi Mattia, Valeri Barbara, Canevari Silvana, Colombatti Alfonso, Belletti Barbara, Del Sal Giannino, Baldassarre Gustavo

Abstract excerpt

Stathmin is a p53-target gene, frequently overexpressed in late stages of human cancer progression. Type II High Grade Epithelial Ovarian Carcinomas (HG-EOC) represents the only clear exception to this observation. Here, we show that stathmin expression is necessary for the survival of HG-EOC cells carrying a p53 mutant (p53(MUT) ) gene. At molecular level, stathmin favours the binding and the phosphorylation of...

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PMID: 23610071
DOI: 10.1002/emmm.201201504
PMCID: PMC3662314

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