Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation

1 Aug 2008

Abstract excerpt

The cellular response to Nutlin-3, a small-molecule inhibitor of the p53 repressor MDM2, varies widely among human cancer-derived cell types. Whereas HCT116 colorectal carcinoma cells display sustained cell cycle arrest, BV173 leukemia cells undergo rapid apoptosis and other cell lines show an intermediate response. We found that the expression of the p53 target genes p21, 14-3-3sigma and the microRNA miR-34a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 protein interactions
Share to Cancer-related Molecular Pathways
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18677110
DOI: 10.4161/cc.6420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activationPMID 18677110Read ↗

Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosisSemantic proximity Read ↗

Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End.Semantic proximity Read ↗

Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis.Semantic proximity Read ↗

Differential p53-Mediated Cellular Responses to DNA-Damaging Therapeutic AgentsSemantic proximity Read ↗

microRNA-34a promotes DNA damage and mitotic catastrophe.Semantic proximity Read ↗

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapySemantic proximity Read ↗

Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cellsSemantic proximity Read ↗

Transcriptional activation of miR-34a contributes to p53-mediated apoptosis.Semantic proximity Read ↗

Rap2b, a novel p53 target, regulates p53-mediated pro-survival functionSemantic proximity Read ↗

Global Genechip Profiling to Identify Genes Responsive to p53-Induced Growth Arrest and Apoptosis in Human Lung Carcinoma CellsSemantic proximity Read ↗

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma CellsSemantic proximity Read ↗

Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.