Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells

1 Feb 2007

Abstract excerpt

We have recently shown that thymoquinone (TQ) is an antineoplastic drug that induces p53-dependent apoptosis in human colon cancer cells. This study evaluated the antiproliferative and pro-apoptotic effects of TQ in two human osteosarcoma cell lines with different p53 mutation status. TQ decreased cell survival dose-dependently and, more significantly, in p53-null MG63 cells (IC(50) = 17 muM) than in p53-mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bioactive Compounds and Antitumor Agents
Share to Chemotherapy-induced organ toxicity mitigation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17218778
DOI: 10.4161/cbt.6.2.3575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cellsPMID 17218778Read ↗

Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanismSemantic proximity Read ↗

Theabrownin triggers DNA damage to suppress human osteosarcoma U2 OS cells by activating p53 signalling pathwaySemantic proximity Read ↗

Molecular mechanisms of G<sub>0</sub>/G<sub>1</sub> cell‐cycle arrest and apoptosis induced by terfenadine in human cancer cellsSemantic proximity Read ↗

Differential antiproliferative mechanisms of novel derivative of benzimidazo[1,2- α ]quinoline in colon cancer cells depending on their p53 statusSemantic proximity Read ↗

Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.Semantic proximity Read ↗

Quinacrine-Mediated Autophagy and Apoptosis in Colon Cancer Cells Is Through a p53- and p21-Dependent MechanismSemantic proximity Read ↗

Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells.Semantic proximity Read ↗

Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatmentSemantic proximity Read ↗

Securinine induces p73‐dependent apoptosis preferentially in p53‐deficient colon cancer cellsSemantic proximity Read ↗

A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: hypersensitivity of p53-mutant human tumour xenografts.Semantic proximity Read ↗

Thymoquinone, a bioactive component of black caraway seeds, causes G1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells with mutant p53.Semantic proximity Read ↗

An evaluation of the ability of pifithrin-α and -β to inhibit p53 function in two wild-type p53 human tumor cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.