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Article

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

Molecular immunology - 1 Mar 2006

Reilly Brian D

Abstract excerpt

The fourth component of human complement is an essential part of the classical and lectin pathways performing multifunctional roles in both host defense and immune regulation. C4 is the most polymorphic member of the complement proteins, and complete deficiency is strongly associated with autoimmune disease, especially, systemic lupus erythematosus (SLE). Of the two C4 genes C4A, but not C4B, null alleles have...

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Identifiers

PMID: 16098595
DOI: 10.1016/j.molimm.2005.07.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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