Article
Screening and SNP mapping of copper-resistant mutations in C. elegans.
Yi chuan = Hereditas - 1 Dec 2014
Song Shaojuan, Guo Yaping, Zhang Xueyao, Zhang Jianzhen, Ma Enbo
Abstract excerpt
Copper plays critical roles in biological system; however, it is toxic in excess. To identify novel genes involved in copper metabolism, we performed a whole genome-wide genetic screen in C. elegans model organism to search for mutants which are resistant to excessive copper. Wild type (N2) L4 worms were mutagenized with ethylmethane sulfonate (EMS), and the F₂progeny were screened on culture medium with excess...
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