Article
Preferential occurrence of spliceosome mutations in acute myeloid leukemia with preceding myelodysplastic syndrome and/or myelodysplasia morphology.
Leukemia & lymphoma - 1 Jan 2015
Cho Young-Uk, Jang Seongsoo, Seo Eul-Ju, Park Chan-Jeoung, Chi Hyun-Sook, Kim Dae-Young, Lee Jung-Hee, Lee Je-Hwan, Lee Kyoo-Hyung, Koh Kyung-Nam, Im Ho-Joon, Seo Jong Jin, Park Sang Hyuk, Park Young-Mi, Lee Jong-Keuk
Abstract excerpt
Spliceosome mutations are associated with myelodysplasia. Here, we aimed to evaluate the frequency and clinical associations of these mutations in 204 patients with acute myeloid leukemia with myelodysplasia-related changes (AML with MRC) and 37 with therapy-related AML (t-AML). The frequency of mutation-positive patients was 17.0%, including U2AF1 (8.3%), SRSF2 (5.8%) and SF3B1 (2.9%). Mutations were detected...
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