Article
Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome.
Haematologica - 1 Jul 2013
Mian Syed A, Smith Alexander E, Kulasekararaj Austin G, Kizilors Aytug, Mohamedali Azim M, Lea Nicholas C, Mitsopoulos Konstantinos, Ford Kevin, Nasser Erick, Seidl Thomas, Mufti Ghulam J
Abstract excerpt
The recent identification of acquired mutations in key components of the spliceosome machinery strongly implicates abnormalities of mRNA splicing in the pathogenesis of myelodysplastic syndromes. However, questions remain as to how these aberrations functionally combine with the growing list of mutations in genes involved in epigenetic modification and cell signaling/transcription regulation identified in these...
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