Frequent pathway mutations of splicing machinery in myelodysplasia.

doi:10.1038/nature10496

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Frequent pathway mutations of splicing machinery in myelodysplasia.

Nature - 11 Sept 2011

Yoshida Kenichi, Sanada Masashi, Shiraishi Yuichi, Nowak Daniel, Nagata Yasunobu, Yamamoto Ryo, Sato Yusuke, Sato-Otsubo Aiko, Kon Ayana, Nagasaki Masao, Chalkidis George, Suzuki Yutaka, Shiosaka Masashi, Kawahata Ryoichiro, Yamaguchi Tomoyuki, Otsu Makoto, Obara Naoshi, Sakata-Yanagimoto Mamiko, Ishiyama Ken, Mori Hiraku, Nolte Florian, Hofmann Wolf-Karsten, Miyawaki Shuichi, Sugano Sumio, Haferlach Claudia, Koeffler H Phillip, Shih Lee-Yung, Haferlach Torsten, Chiba Shigeru, Nakauchi Hiromitsu, Miyano Satoru, Ogawa Seishi

Abstract excerpt

Myelodysplastic syndromes and related disorders (myelodysplasia) are a heterogeneous group of myeloid neoplasms showing deregulated blood cell production with evidence of myeloid dysplasia and a predisposition to acute myeloid leukaemia, whose pathogenesis is only incompletely understood. Here we report whole-exome sequencing of 29 myelodysplasia specimens, which unexpectedly revealed novel pathway mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Spliceosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exome

Share to Hematopoiesis

Share to Myelodysplastic Syndromes

Share to Ribonucleoproteins

Share to RNA Splice Sites

Share to RNA Splicing

Share to Splicing Factor U2AF

Source

Open in PubMed

Identifiers

PMID: 21909114
DOI: 10.1038/nature10496

Genes

SRSF2
ZRSR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent pathway mutations of splicing machinery in myelodysplasia.PMID 21909114Read ↗

Frequent Pathway Mutations of Splicing Machinery in MyelodysplasiaSemantic proximity Read ↗

Mechanistic Insights of Aberrant Splicing with Splicing Factor Mutations Found in Myelodysplastic Syndromes.Semantic proximity Read ↗

Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.Semantic proximity Read ↗

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis.Semantic proximity Read ↗

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.Semantic proximity Read ↗

Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia.Semantic proximity Read ↗

Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes.Semantic proximity Read ↗

[Role of Aberrant Splicing in Pathogenesis of Myelodysplastic Syndromes-Review].Semantic proximity Read ↗

Splicing factor mutations in myelodysplasia.Semantic proximity Read ↗

Splicing factor mutations and cancer.Semantic proximity Read ↗

RNA splicing as a therapeutic target in myelodysplastic syndromes.Semantic proximity Read ↗

Splicing factor mutations in the myelodysplastic syndromes: Role of key aberrantly spliced genes in disease pathophysiology and treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.