Article
Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.
Nature medicine - 1 Jan 2015
Yoda Akinori, Adelmant Guillaume, Tamburini Jerome, Chapuy Bjoern, Shindoh Nobuaki, Yoda Yuka, Weigert Oliver, Kopp Nadja, Wu Shuo-Chieh, Kim Sunhee S, Liu Huiyun, Tivey Trevor, Christie Amanda L, Elpek Kutlu G, Card Joseph, Gritsman Kira, Gotlib Jason, Deininger Michael W, Makishima Hideki, Turley Shannon J, Javidi-Sharifi Nathalie, Maciejewski Jaroslaw P, Jaiswal Siddhartha, Ebert Benjamin L, Rodig Scott J, Tyner Jeffrey W, Marto Jarrod A, Weinstock David M, Lane Andrew A
Abstract excerpt
Activating mutations in genes encoding G protein α (Gα) subunits occur in 4-5% of all human cancers, but oncogenic alterations in Gβ subunits have not been defined. Here we demonstrate that recurrent mutations in the Gβ proteins GNB1 and GNB2 confer cytokine-independent growth and activate canonical G protein signaling. Multiple mutations in GNB1 affect the protein interface that binds Gα subunits as well as...
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