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Article

Rapid identification of an antibody DNA construct rearrangement sequence variant by mass spectrometry.

mAbs - 1 Jan 2014

Scott Rebecca A, Rogers Rich, Balland Alain, Brady Lowell J

Abstract excerpt

During cell line development for an IgG1 antibody candidate (mAb1), a C-terminal extension was identified in 2 product candidate clones expressed in CHO-K1 cell line. The extension was initially observed as the presence of anomalous new peaks in these clones after analysis by cation exchange chromatography (CEX-HPLC) and reduced capillary electrophoresis (rCE-SDS). Reduced mass analysis of these CHO-K1 clones...

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Identifiers

PMID: 25484040
DOI: 10.4161/mabs.36222
PMCID: PMC4622602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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