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Eliminating tyrosine sequence variants in CHO cell lines producing recombinant monoclonal antibodies

25 Oct 2012

Abstract excerpt

Amino acid sequence variants are defined as unintended amino acid sequence changes that contribute to product variation with potential impact to product safety, immunogenicity, and efficacy. Therefore, it is important to understand the propensity for sequence variant (SV) formation during the production of recombinant proteins for therapeutic use. During the development of clinical therapeutic products, several...

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PMID: 23108857
DOI: 10.1002/bit.24759

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