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Article

ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis.

Molecular cancer - 7 Nov 2019

Lin Qiushi, Chen Xuesong, Meng Fanzheng, Ogawa Kosuke, Li Min, Song Ruipeng, Zhang Shugeng, Zhang Ziran, Kong Xianglu, Xu Qinggang, He Fuliang, Bai Xuewei, Sun Bei, Hung Mien-Chie, Liu Lianxin, Wands Jack, Dong Xiaoqun

Abstract excerpt

BACKGROUND: Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication. This study aims to explore molecular mechanisms underlying how ASPH network regulates designated...

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Identifiers

PMID: 31694640
DOI: 10.1186/s12943-019-1077-0
PMCID: PMC6836474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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