Article
Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Mar 2000
Adell T, Gómez-Cuadrado A, Skoudy A, Pettengill O S, Longnecker D S, Real F X
Abstract excerpt
The majority of human pancreatic adenocarcinomas display a ductal phenotype; experimental studies indicate that tumors with this phenotype can arise from both acinar and ductal cells. In normal pancreas acinar cells, the pancreas transcription factor 1 transcriptional complex is required for gene expression. Pancreas transcription factor 1 is a heterooligomer of pancreas-specific (p48) and ubiquitous (p75/E2A and...
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