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Article

EDI3 links choline metabolism to integrin expression, cell adhesion and spreading

23 May 2014

Abstract excerpt

Endometrial carcinoma differential 3 (EDI3) was the first member of the glycerophosphodiesterase (GDE) protein family shown to be associated with cancer. Our initial work demonstrated that endometrial and ovarian cancer patients with primary tumors overexpressing EDI3 had a higher risk of developing metastasis and decreased survival. Further analysis indicated that EDI3 cleaves glycerophosphocholine to choline...

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PMID: 25482527
DOI: 10.4161/cam.29284

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