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Article

ApoE-isoform-dependent cellular uptake of amyloid-β is mediated by lipoprotein receptor LR11/SorLA.

Biochemical and biophysical research communications - 2 Jan 2015

Yajima Ryuji, Tokutake Takayoshi, Koyama Akihide, Kasuga Kensaku, Tezuka Toshiyuki, Nishizawa Masatoyo, Ikeuchi Takeshi

Abstract excerpt

The formation of senile plaques composed of β-amyloid (Aβ) in the brain is likely the initial event in Alzheimer's disease (AD). Possession of the APOE ε4 allele, the strong genetic factor for AD, facilitates the Aβ deposition from the presymptomatic stage of AD in a gene-dosage-dependent manner. However, the precise mechanism by which apoE isoforms differentially induce the AD pathology is largely unknown....

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Source

Identifiers

PMID: 25482438
DOI: 10.1016/j.bbrc.2014.11.111

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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