Article
KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 May 2015
Eshleman James R, Norris Alexis L, Sadakari Yoshihiko, Debeljak Marija, Borges Michael, Harrington Colleen, Lin Elaine, Brant Aaron, Barkley Thomas, Almario J Alejandro, Topazian Mark, Farrell James, Syngal Sapna, Lee Jeffrey H, Yu Jun, Hruban Ralph H, Kanda Mitsuro, Canto Marcia Irene, Goggins Michael
Abstract excerpt
BACKGROUND & AIMS: Pancreatic imaging can identify neoplastic cysts but not microscopic neoplasms. Mutation analysis of pancreatic fluid after secretin stimulation might identify microscopic neoplasias in the pancreatic duct system. We determined the prevalence of mutations in KRAS and guanine nucleotide-binding protein α-stimulating genes in pancreatic juice from subjects undergoing endoscopic ultrasound for...
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