KRAS Mutations in Duodenal Lavage Fluid After Secretin Stimulation for Detection of Pancreatic Cancer.

doi:10.1097/SLA.0000000000006645

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Article

KRAS Mutations in Duodenal Lavage Fluid After Secretin Stimulation for Detection of Pancreatic Cancer.

Annals of surgery - 1 Oct 2026

Yachida Shinichi, Yoshinaga Shigetaka, Shiba Satoshi, Urabe Makiko, Tanaka Hidenori, Takeda Yohei, Shimizu Akinori, Sakamoto Yuri, Hijioka Susumu, Haba Shin, Ashida Reiko, Kushiyama Yoshinori, Asano Kento, Kobayashi Makiko, Murawaki Yoshiyuki, Onishi Kouji, Yamashita Taro, Kimura Hirokazu, Totoki Yasushi, Kamada Hideki, Isomoto Hajime, Hattori Satoshi, Morizane Chigusa, Ohkawa Kazuyoshi, Kitano Masayuki, Hara Kazuo, Ikezawa Kenji, Hanada Keiji, Matsumoto Kazuya

Abstract excerpt

OBJECTIVE: Although pancreatic ductal adenocarcinoma (PDAC) is still a devastating disease, the survival rate for surgically removed PDACs has significantly improved in recent years. Early detection is essential in managing PDAC. BACKGROUND: The presence of KRAS mutations in PDAC leads to the initial genetic abnormality and offers a significant timeframe for identifying resectable PDACs. A minimally invasive and...

Read the complete abstract on PubMed

Topics

Humans
Secretin
Pancreatic Neoplasms
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Carcinoma, Pancreatic Ductal

Female

Male

Middle Aged

Aged

Early Detection of Cancer

Duodenum

Pancreatic Juice

Endoscopy, Digestive System

Source

Open in PubMed Open full text

Identifiers

PMID: 39902566
DOI: 10.1097/SLA.0000000000006645
PMCID: PMC13557476

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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