Article
A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.
Science (New York, N.Y.) - 8 Dec 2017
Zhou Yiming, Castonguay Philip, Sidhom Eriene-Heidi, Clark Abbe R, Dvela-Levitt Moran, Kim Sookyung, Sieber Jonas, Wieder Nicolas, Jung Ji Yong, Andreeva Svetlana, Reichardt Jana, Dubois Frank, Hoffmann Sigrid C, Basgen John M, Montesinos Mónica S, Weins Astrid, Johnson Ashley C, Lander Eric S, Garrett Michael R, Hopkins Corey R, Greka Anna
Abstract excerpt
Progressive kidney diseases are often associated with scarring of the kidney's filtration unit, a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of podocytes, cells critical for glomerular filtration, and leads to proteinuria and kidney failure. Inherited forms of FSGS are caused by Rac1-activating mutations, and Rac1 induces TRPC5 ion channel activity and cytoskeletal...
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