Article
Blocking the Rac1-TRPC5 pathway protects human podocytes
2020-08-29
Abstract excerpt
Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5 channels with small-molecule inhibitors protects podocytes in rodent models of disease, but less is known about the human relevance and translatability of TRPC5 inhibition. Here, we investigate the effect of TRPC5 inhibition in puromycin aminonucleoside (PAN)-...
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Identifiers and source
- Literature Corpus work
- 90b83efe-d2e1-5d47-9bbc-7fd5efbb71f5
- DOI
- 10.1101/2020.08.28.272344