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IgSF11–RAP1 signaling promotes cell migration and invasion of cutaneous melanoma

10 Jul 2025

Abstract excerpt

Aberrant cell adhesion signaling is known to either accelerate or inhibit cancer progression, but the underlying molecular basis has yet to be established. The immunoglobulin superfamily 11 (IgSF11) functions as a cell adhesion protein and is overexpressed in several types of cancer, including high-grade glioma. However, it remains unknown whether and how IgSF11 stimulates malignant phenotypes. Using The Cancer...

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PMID: 40635001
DOI: 10.1186/s12964-025-02245-5

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