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Article

TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR.

Oncotarget - 15 Dec 2014

Wang Kun, Liu Tiantian, Ge Nan, Liu Li, Yuan Xiaotian, Liu Jikai, Kong Feng, Wang Chang, Ren Hongbo, Yan Keqiang, Hu Sanyuan, Xu Zhonghua, Björkholm Magnus, Fan Yidong, Zhao Shengtian, Liu Cheng, Xu Dawei

Abstract excerpt

TERT promoter C228T and C250T mutations occur in various malignancies including bladder cancer (BC) and may serve as urinary tumor markers. However, the mutation association with clinical variables in upper tract urothelial carcinomas (UTUCs) is unclear. There is also a lack of sensitive tools to detect the minor mutant TERT promoter in bulk urinary DNA. Here we analyzed 220 UTUC patients [98 with renal pelvic...

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Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Transitional Cell

Share to Kidney Neoplasms

Share to Neoplasm Metastasis

Share to Promoter Regions, Genetic

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Identifiers

PMID: 25474136
DOI: 10.18632/oncotarget.2660
PMCID: PMC4322995

Genes

TERT

Variants

Provenance

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