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Article

Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer's disease.

Brain : a journal of neurology - 1 Jan 2015

Cantarella Giuseppina, Di Benedetto Giulia, Puzzo Daniela, Privitera Lucia, Loreto Carla, Saccone Salvatore, Giunta Salvatore, Palmeri Agostino, Bernardini Renato

Abstract excerpt

Alzheimer's disease is one of the most common causes of death worldwide, with poor treatment options. A tissue landmark of Alzheimer's disease is accumulation of the anomalous protein amyloid-β in specific brain areas. Whether inflammation is an effect of amyloid-β on the Alzheimer's disease brain, or rather it represents a cause for formation of amyloid plaques and intracellular tangles remains a subject of...

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Identifiers

PMID: 25472798
DOI: 10.1093/brain/awu318
PMCID: PMC4441080

Genes

TNFSF10
GFAP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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