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Article

Caspase-6 Knockout in the 5xFAD Model of Alzheimer's Disease Reveals Favorable Outcome on Memory and Neurological Hallmarks.

International journal of molecular sciences - 9 Feb 2020

Angel Ariel, Volkman Rotem, Royal Tabitha Grace, Offen Daniel

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most common form of dementia in the elderly. Caspases, a family of cysteine proteases, are major mediators of apoptosis and inflammation. Caspase-6 is considered to be an up-stream modulator of AD pathogenesis as active caspase-6 is abundant in neuropil threads, neuritic plaques, and neurofibrillary tangles of AD brains. In order to...

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PMID: 32050445
DOI: 10.3390/ijms21031144
PMCID: PMC7037950

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