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Article

Early retinal function deficit without prominent morphological changes in the R6/2 mouse model of Huntington's disease.

PloS one - 1 Jan 2014

Ragauskas Symantas, Leinonen Henri, Puranen Jooseppi, Rönkkö Seppo, Nymark Soile, Gurevicius Kestutis, Lipponen Arto, Kontkanen Outi, Puoliväli Jukka, Tanila Heikki, Kalesnykas Giedrius

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder that primarily affects the medium-size GABAergic neurons of striatum. The R6/2 mouse line is one of the most widely used animal models of HD. Previously the hallmarks of HD-related pathology have been detected in photoreceptors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25469887
DOI: 10.1371/journal.pone.0113317
PMCID: PMC4254453

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25469887-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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