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Article

Retinal dysfunction, photoreceptor protein dysregulation and neuronal remodelling in the R6/1 mouse model of Huntington's disease.

Neurobiology of disease - 1 Mar 2012

Batcha Abrez Hussain, Greferath Una, Jobling Andrew I, Vessey Kirstan A, Ward Michelle M, Nithianantharajah Jess, Hannan Anthony J, Kalloniatis Michael, Fletcher Erica L

Abstract excerpt

Huntington's disease (HD) is a progressive neurological disease characterised by motor dysfunction, cognitive impairment and personality changes. Previous work in HD patients and animal models of the disease has also highlighted retinal involvement. This study characterised the changes in retinal structure and function early within the progression of disease using the R6/1 mouse model of HD. The retinal phenotype...

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Identifiers

PMID: 22198376
DOI: 10.1016/j.nbd.2011.12.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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