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Article

Fine‐structural analysis and connexin expression in the retina of a transgenic model of Huntington's disease

27 Sept 2004

Abstract excerpt

Recent studies indicate that the visual system appears more frequently affected in polyglutamine diseases than expected previously. Here, we investigated retinal degenerations in adult transgenic R6/2 mice, a model for Huntington's disease (HD). Light microscopical analysis revealed retinal dystrophy all over the retina, with central areas showing major effects. Electron microscopical analysis showed strong...

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PMID: 15452853
DOI: 10.1002/cne.20327

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