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Article

Causes and consequences of microsatellite instability in gastric carcinogenesis.

World journal of gastroenterology - 28 Nov 2014

Velho Sérgia, Fernandes Maria Sofia, Leite Marina, Figueiredo Ceu, Seruca Raquel

Abstract excerpt

Loss of DNA mismatch repair (MMR) function, due to somatic or germline epi/genetic alterations of MMR genes leads to the accumulation of numerous mutations across the genome, creating a molecular phenotype known as microsatellite instability (MSI). In gastric cancer (GC), MSI occurs in about 15% to 30% of the cases. This review summarizes the current knowledge on the molecular mechanisms underlying the...

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Identifiers

PMID: 25469011
DOI: 10.3748/wjg.v20.i44.16433
PMCID: PMC4248186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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