Article
Interplay between mTOR and STAT5 signaling modulates the balance between regulatory and effective T cells.
Immunobiology - 1 Apr 2015
Shan Juan, Feng Li, Sun Guixiang, Chen Peng, Zhou Yanni, Xia Mengjuan, Li Hongsheng, Li Youping
Abstract excerpt
BACKGROUND: Immune response outcome, inflammation or tolerance, often depends on the balance between regulatory T cells (Tregs) and effective T cells (Teffs). Rapamycin (Rapa) has been reported to selectively expand Tregs and promote de novo generation of foxp3(+) Tregs, suggesting its potential role in inducing tolerance. But the mechanism by which Rapa regulating the Treg-Teff balance is yet to be understood....
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