Article
The influence of mTOR inhibitors on immunity and the relationship to post-transplant malignancy
1 Nov 2013
Abstract excerpt
The known role of mammalian target of rapamycin (mTOR) in the immune response has been rapidly evolving, from what was once thought to be a simple immunosuppressive antiproliferative effect on T cells to a very complex central role that serves to integrate multiple signals given to T cells, B cells and antigen-presenting cells. The complexity of this topic is demonstrated by recent data suggesting that mTOR...
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