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Article

JAK2 and AMP-kinase inhibition in vitro by food extracts, fractions and purified phytochemicals.

Food & function - 1 Jan 2015

Martin Harry, Burgess Elaine J, Smith Wendy A, McGhie Tony K, Cooney Janine M, Lunken Rona C M, de Guzman Erika, Trower Tania, Perry Nigel B

Abstract excerpt

We have identified a range of food phytochemicals that inhibit Janus Kinase 2 (JAK2) and Adenosine Monophosphate Kinase (AMPK). A mutated and dysregulated form of JAK2, a tyrosine kinase, is associated with several diseases including Crohn's disease. Using an in vitro, time-resolved fluorescence (TR-FRET) assay, we tested 49 different types of food extracts, plus 10 concentrated fractions of increasing...

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Identifiers

PMID: 25463744
DOI: 10.1039/c4fo00626g

Genes

JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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