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Article

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2010

Suen Der-Fen, Narendra Derek P, Tanaka Atsushi, Manfredi Giovanni, Youle Richard J

Abstract excerpt

Mitochondrial genomes with deleterious mutations can replicate in cells along with wild-type genomes in a state of heteroplasmy, and are a cause of severe inherited syndromes, such as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke (MELAS), neuropathy, ataxia, retinitis pigmen...

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Identifiers

PMID: 20547844
DOI: 10.1073/pnas.0914569107
PMCID: PMC2900690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20547844-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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