Article
Post receptor determinants of acute platelet response to clopidogrel in patients with symptomatic myocardial ischemia.
Vascular pharmacology - 1 Jan 2000
Nooney V B, Hurst N L, Chirkov Y Y, De Caterina R, Horowitz J D
Abstract excerpt
BACKGROUND: Clopidogrel resistance is more common in patients with loss-of-function CYP2C19 genotypes. Since adenylate cyclase (AC) and soluble guanylate cyclase (sGC) pathways are variably impaired in patients with ischaemic heart disease, we tested the relevance of these determinants in patient...
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