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Article

Adrenergic receptor polymorphisms and platelet reactivity after treatment with dual antiplatelet therapy with aspirin and clopidogrel in acute coronary syndrome.

Thrombosis and haemostasis - 1 Apr 2010

Cuisset Thomas, Hamilos Michalis, Delrue Michalis, Frère Corinne, Verhamme Katia, Bartunek Jozef, Saut Noemie, Bonnet Jean Louis, Eijgelsheim Mark, Wijns William, Alessi Marie-Christine, Barbato Emanuele

Abstract excerpt

Platelet response to clopidogrel shows inter-individual variability that is partially explained by genetic polymorphisms. This variability affects clinical outcome when clopidogrel is administered in patients with acute coronary syndrome (ACS). Catecholamines, released during ACS, contribute to platelet aggregation through platelet alpha2A-(alpha2A-AR) and beta2-adrenergic receptor (beta2-AR) stimulation. It was...

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Source

Identifiers

PMID: 20135061
DOI: 10.1160/TH09-06-0355

Genes

VASP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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