Article
In Vivo Expansion of Antigen-Specific Regulatory T Cells through Staggered Fc.IL-2 Mutein Dosing and Antigen-Specific Immunotherapy.
ImmunoHorizons - 28 Sept 2021
Pham Minh N, Khoryati Liliane, Jamison Braxton L, Hayes Erika, Sullivan Jenna M, Campbell Daniel J, Gavin Marc A
Abstract excerpt
In mice, Ag administration in the absence of adjuvant typically elicits tolerogenic immune responses through the deletion or inactivation of conventional CD4 T cells and the formation or expansion of regulatory CD4 T cells (Treg). Although these "Ag-specific immunotherapy" (ASI) approaches are currently under clinical development to treat autoinflammatory conditions, efficacy and safety may be variable and...
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