Association of diabetes and PNPLA3 genetic variants with disease severity of patients with chronic hepatitis C virus infection.

doi:10.1016/j.jhep.2014.10.011

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Article

Association of diabetes and PNPLA3 genetic variants with disease severity of patients with chronic hepatitis C virus infection.

Journal of hepatology - 1 Mar 2015

Huang Chung-Feng, Dai Chia-Yen, Yeh Ming-Lun, Huang Ching-I, Tai Chi-Ming, Hsieh Meng-Hsuan, Liang Po-Cheng, Lin Yi-Hung, Hsieh Ming-Yen, Yang Hua-Ling, Huang Jee-Fu, Lin Zu-Yau, Chen Shinn-Cherng, Yu Ming-Lung, Chuang Wan-Long

Abstract excerpt

BACKGROUND & AIMS: Genetic variants of patatin-like phospholipase domain-containing 3 (PNPLA3) and diabetes are associated with liver disease severity, in patients with chronic hepatitis C (CHC) infection. We aimed at exploring their interaction in determining hepatitis C virus (HCV)-related liver fibrosis. METHODS: The PNPLA3 genetic polymorphism at rs738409 was verified in 1077 biopsy-proven CHC patients. Other...

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PMID: 25457210
DOI: 10.1016/j.jhep.2014.10.011

Genes

PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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