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Article

The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.

Cell reports - 20 Nov 2014

Mannion Niamh M, Greenwood Sam M, Young Robert, Cox Sarah, Brindle James, Read David, Nellåker Christoffer, Vesely Cornelia, Ponting Chris P, McLaughlin Paul J, Jantsch Michael F, Dorin Julia, Adams Ian R, Scadden A D J, Ohman Marie, Keegan Liam P, O'Connell Mary A

Abstract excerpt

The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration. Adar1 mutant mouse embryos show aberrant interferon induction and die by embryonic day E12.5. We demonstrate that Adar1 embryonic lethality is rescued to live birth...

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Share to Adenosine Deaminase
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25456137
DOI: 10.1016/j.celrep.2014.10.041
PMCID: PMC4542304

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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