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Article

IRF5 is a target of BCR-ABL kinase activity and reduces CML cell proliferation

20 Jan 2014

Abstract excerpt

Interferon regulatory factor 5 (IRF5) modulates the expression of genes controlling cell growth and apoptosis. Previous findings have suggested a lack of IRF5 transcripts in both acute and chronic leukemias. However, to date, IRF5 expression and function have not been investigated in chronic myeloid leukemia (CML). We report that IRF5 is expressed in CML cells, where it interacts with the BCR-ABL kinase that...

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PMID: 24445143
DOI: 10.1093/carcin/bgu013

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