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Article

Concurrence of B-lymphoblastic leukemia and myeloproliferative neoplasm with copy neutral loss of heterozygosity at chromosome 1p harboring a MPL W515S mutation.

Cancer genetics - 1 Jan 2000

Tao Jiangchuan, Zhang Xiaohui, Lancet Jeffrey, Bennett John M, Cai Li, Papenhausen Peter, Moscinski Lynn, Zhang Ling

Abstract excerpt

B-lymphoblastic leukemia (B-ALL) is a neoplasm of precursors committed to B-cell lineage, whereas myeloproliferative neoplasm (MPN) is a clonal proliferation derived from myeloid stem cells. Concurrent B-ALL with MPN is uncommon except in the presence of abnormalities of the PDGFRA, PDGFRB, or FGFR1 genes or the BCR-ABL1 fusion gene. Herein, we describe a rare concurrence, B-ALL with MPN without the...

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Topics

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Share to Chromosomes, Human, Pair 1
Share to Cytogenetic Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Myeloproliferative Disorders

Share to Oligonucleotide Array Sequence Analysis

Share to Polymorphism, Single Nucleotide

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptors, Thrombopoietin

Source

Identifiers

PMID: 25453399
DOI: 10.1016/j.cancergen.2014.10.001

Genes

MPL
ABL1
BCR
FGFR1
PDGFRA
PDGFRB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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