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Article

Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 Mutation: Comparison With Pediatric Patients.

American journal of clinical pathology - 1 Aug 2015

Fang Min, Becker Pamela S, Linenberger Michael, Eaton Keith D, Appelbaum Frederick R, Dreyer ZoAnn, Airewele Gladstone, Redell Michele, Lopez-Terrada Dolores, Patel Ankita, Rabin Karen R, Lu Xinyan

Abstract excerpt

OBJECTIVES: Chromosomal ploidy is a major risk stratification tool for acute B-cell lymphoblastic leukemia (B-ALL). Low hypodiploidy and near-haploidy are thought to be confined to pediatric B-ALL and associated with a poor prognosis. Doubling of either a low-hypodiploid or a near-haploid clone results in an apparently high-hyperdiploid karyotype, which is often misclassified for risk. METHODS: We studied four...

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Share to Ikaros Transcription Factor
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Karyotyping

Share to Oligonucleotide Array Sequence Analysis

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

Identifiers

PMID: 26185311
DOI: 10.1309/AJCPW83OXPYKPEEN

Genes

IKZF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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