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Article

Myeloproliferative neoplasms with t(8;22)(p11.2;q11.2)/BCR-FGFR1: a meta-analysis of 20 cases shows cytogenetic progression with B-lymphoid blast phase.

Human pathology - 1 Jul 2017

Montenegro-Garreaud Ximena, Miranda Roberto N, Reynolds Alexandra, Tang Guilin, Wang Sa A, Yabe Mariko, Wang Wei, Fang Lianghua, Bueso-Ramos Carlos E, Lin Pei, Medeiros L Jeffrey, Lu Xinyan

Abstract excerpt

Rearrangements of FGFR1 result in the 8p11 myeloproliferative syndrome, a group of rare diseases that features a myeloproliferative neoplasm (MPN) that commonly progresses to lymphoblastic leukemia/lymphoma or acute myeloid leukemia. The most common partner of FGFR1 is ZMYM2, and patients with the ZMYM2-FGFR1 fusion often present with MPN and T-lymphoblastic lymphoma. There are 14 other partners that can fuse...

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Share to Chromosomes, Human, Pair 22
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

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Source

Identifiers

PMID: 28551329
DOI: 10.1016/j.humpath.2017.05.008

Genes

FGFR1
BCR
ZMYM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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