Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The co-occurrence of driver mutations in chronic myeloproliferative neoplasms.

Annals of hematology - 1 Nov 2018

Boddu Prajwal, Chihara Dai, Masarova Lucia, Pemmaraju Naveen, Patel Keyur P, Verstovsek Srdan

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are clonal disorders characterized by proliferation of one or more elements of the myeloid lineage. Key genetic aberrations include the BCR-ABL1 gene rearrangement in Philadelphia chromosome-positive chronic myelogenous leukemia (CML) and JAK2/MPL/CALR aberrations in Philadelphia chromosome-negative MPNs. While thought to be mutually exclusive, occasional isolated reports of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to CALR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MPL gene

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Mutation

Share to Neoplasm Proteins

Share to Philadelphia Chromosome

Source

Identifiers

PMID: 29951914
DOI: 10.1007/s00277-018-3402-x

Genes

JAK2
ABL1
BCR
CALR
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The co-occurrence of driver mutations in chronic myeloproliferative neoplasms.PMID 29951914Read ↗

Co-occurrence of JAK2-V617 F mutation and BCR::ABL1 translocation in chronic myeloproliferative neoplasms: a potentially confounding genetic combinationSemantic proximity Read ↗

Myeloproliferative neoplasms with concurrent BCR-ABL1 translocation and JAK2 V617F mutation: a multi-institutional study from the bone marrow pathology group.Semantic proximity Read ↗

Genetic and Clinical Characteristics of Patients with Philadelphia-Negative Myeloproliferative Neoplasm Carrying Concurrent Mutations in JAK2V617F, CALR, and MPL.Semantic proximity Read ↗

Concomitant BCR-ABL1 translocation and JAK2(V617F) mutation in three patients with myeloproliferative neoplasms.Semantic proximity Read ↗

Co-existence of mutations in myeloproliferative neoplasms and their clinical significance: a prognostic approach.Semantic proximity Read ↗

Presence of triple positive driver mutations in JAK2, CALR and MPL in primary myelofibrosis: a case report and literature review.Semantic proximity Read ↗

Two myeloproliferative diseases in one patient - co-occurence of clonesSemantic proximity Read ↗

A Rare Case of Essential Thrombocythemia with Coexisting JAK2 and MPL Driver Mutations.Semantic proximity Read ↗

Coexisting driver mutations in MPN: clinical and molecular characteristics of a series of 11 patients.Semantic proximity Read ↗

Clinical and biological characterization of MPN patients harboring two driver mutations, a F rench intergroup of myeloproliferative neoplasms (FIM) studySemantic proximity Read ↗

Chronic lymphocytic leukemia and myeloproliferative neoplasms concurrently diagnosed: clinical and biological characteristics.Semantic proximity Read ↗

Sequential Development of JAK2V617F Mutation and BCR-ABL1 Fusion in Individual Patients With Myeloproliferative Neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.