Article
Evidence of polyclonality in neurofibromatosis type 2-associated multilobulated vestibular schwannomas.
Neuro-oncology - 1 Apr 2015
Dewan Ramita, Pemov Alex, Kim H Jeffrey, Morgan Keaton L, Vasquez Raul A, Chittiboina Prashant, Wang Xiang, Chandrasekharappa Settara C, Ray-Chaudhury Abhik, Butman John A, Stewart Douglas R, Asthagiri Ashok R
Abstract excerpt
BACKGROUND: Neurofibromatosis type 2 (NF2) is a tumor syndrome that results from mutation of the NF2 tumor suppressor gene. The hallmark of NF2 is the presence of bilateral vestibular schwannoma (VS). Though NF2-associated and sporadic VS share identical histopathologic findings and cytogenetic alterations, NF2-associated VS often appears multilobulated, is less responsive to radiosurgery, and has worse surgical...
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