Article
Global deletion of Ankrd1 results in a wound-healing phenotype associated with dermal fibroblast dysfunction.
The American journal of pathology - 1 Jan 2015
Samaras Susan E, Almodóvar-García Karinna, Wu Nanjun, Yu Fang, Davidson Jeffrey M
Abstract excerpt
The expression of ankyrin repeat domain protein 1 (Ankrd1), a transcriptional cofactor and sarcomeric component, is strongly elevated by wounding and tissue injury. We developed a conditional Ankrd1(fl/fl) mouse, performed global deletion with Sox2-cre, and assessed the role of this protein in cutaneous wound healing. Although global deletion of Ankrd1 did not affect mouse viability or development, Ankrd1(-/-)...
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